Associate Scientist - Purification Process Sciences
AstraZeneca

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the group:

In Purification Process Sciences in Gaithersburg, MD you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

Main Duties & Responsibilities:

The position resides in the Critical Pipeline Reagent Sciences Group (CPRS) contained within the Purification Process Sciences R&D department. Members of the CPRS function work closely with the research scientists and process development scientists to generate pipeline supporting molecules. Position may require weekend work and/or periodic late-nights. Main duties are as follows:

• Generation of biopharmaceutical reagents to advance the R&D AstraZeneca pipeline
• Performing purifications for complex biopharmaceutical drugs such as antibodies, bispecific antibodies, fusion proteins, DuetMabs, pDNA, and viruses
• Performing conjugations of candidate drugs and anti-IDs to support PK/PD studies
• Solving challenging protein purification problems
• Performs technology development projects to increase purification efficiency
• Coordinating closely with the research department, cell culture group, and analytical biotechnology group in order to meet project timelines and company goals
• Analyzing and interpreting analytical and process data
• Maintain accurate records of data and actively participate in laboratory organization
• Professionally deliver results to internal and external audiences
• Supervision: Should be able to function with limited supervision and is expected to work independently on a day-to-day basis. Expectation for independence will increase with time and experience in the position.

Relevant Education & Experience:

BS/BA or MS/MA biology, biochemistry, chemical/biochemical engineering, or related field

Scientist:

• Education: M.S. or B.S. in Chemistry, Biochemistry, Pharmaceutics, Chemical/biochemical Engineering or related field
• Experience: BS with 0+ years or MS with 0+ years in biopharmaceutical industry/Academic lab

Required Skills:

• Highly team-oriented, energetic, critical thinker, organized, capable of multitasking with excellent oral and written skills
• Knowledge of
  • Basic Protein Chemistry
  • Protein Chromatography
  • Purification Process Design for Monoclonal Antibodies and Novel Proteins
  • Basic Analytical Techniques (HPLC and SDS-PAGE Analyses)
  • Protein Modification by Conjugation
  • Statistics Software and DOE Analysis

Desired Skills:

• GLP/GMP experience
• Experience with purification process design
• Troubleshoot and collaboratively resolve complex problems under tight time constraints
• Experience performing protein chromatography using Akta/Akta software
• Experience performing analytical testing

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

Where can I find out more?

Check out our landing page for more information on our BPD group https://careers.astrazeneca.com/bpd

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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