Bioinformatics Scientist
Camris International

Overview

We are seeking a Bioinformatics Scientist to support the National Institutes of Health's National Institute of Allergy and Infectious Diseases' (NIAID) Vaccine Immunology Program in Bethesda, MD. Our NIAID professional, technical, and scientific support personnel are part of a team focused on positively impacting millions of lives around the world. Candidates will work at a diverse and vibrant NIAID worksite to directly support ongoing research activities as a contractor team member. Take the next big step in your career and apply below to help us make a difference.

CAMRIS International is a dynamic clinical research and international development firm that achieves innovative solutions to health and development challenges through high-quality, cost-effective programs and research management services. We combine our proven systems with today's most effective, evidence-based best practices. Our core practice areas include: clinical research; vaccine research, microbiology and infectious disease research, development and production; biodefense; global health security; and HIV/AIDS programs.

Our employees enjoy a diverse, collegial environment where individual contributions matter at all levels. At CAMRIS, you will notably improve the lives of people at home and abroad.

Responsibilities

• Perform computational analysis of Pacific Biosciences SMRT sequencing of HIV envelope.
• Perform sequence data quality control and trimming, CCS generation, unique species determination and read counting.
• Perform downstream analysis of genetic diversity, phylogeny, and amino acid composition.
• Develop, design and implement new next-generation sequence (NGS) data analysis pipelines for existing projects and newly arising projects.
• Compile and consolidate annotations from specified reference sources using Variant Annotation tools.
• Prepare NGS analysis results for presentation at lab meetings and publications.
• Implement validation analysis of developed pipelines through use of known reference or gold standard datasets.
• Maintain records of NGS experiments analyzed and facilitate re-analysis of previous experiments where necessary with ability to track and archive runs using inhouse backup systems.
• Work with laboratory staff on experimental interpretation and design of new experiments.
• Provide statistical support/analysis on research data.
• Develop pipelines to automate the integration of data from phase 2 and phase 3 clinical trials and perform Quality Checks & Monitor controls data.
• Develop Python and R based workflow to standardize and integrate multiple COVID-19 sample's results from different cohorts and assays and upload them into a central NIH Server location using LABKEY platform.
• Develop Python & Bash based workflows to support data analysis of immunoglobulin sequencing for vaccine clinical trials.
• Develop R based data analysis scripts to perform statistical analysis of sera binding assay results for clinical trials.
• Build informatics solutions to support Vaccine Immunology Program(VIP) Metric reports including EQAPOL data uploads and Control Trending Charts.

Qualifications

• Bachelor's degree in science field is required.
• Minimum of five (5) years of related experience is required.
• Demonstrates experience working in a research environment.
• Proficient in MS Office Suite, Python and R.
• Experience with MiSeq, NextSeq500 and Novaseq technology is preferred.
• Current with NGS genomic technologies and data investigation including the ability to troubleshoot existing and newly generated mechanisms.
• Experience with multiple project management and knowledge of quality assurance/regulatory standards within the field.

CAMRIS International LLC offers competitive salaries and comprehensive benefits. Please submit your resume online at www.CAMRIS.com . CAMRIS is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, disability status, or any other characteristic protected by any applicable federal, state, or local law.

Full vaccination against COVID-19, defined as two doses of Moderna, two doses of Pfizer, or one dose of Johnson & Johnson's Janssen, is required for this position.

Employment is contingent upon successful completion of a Public Trust-level background check, a requirement for this position under an active federal contract. The background check process may include, but is not limited to the following: (1) contacting your professional references; (2) verification of previous employment, education and credentials; (3) a criminal background check; (4) use/abuse of federally-controlled substances; and (5) a department of motor vehicle check. Candidates must be prepared to fully-complete any required background check questionnaire during initial onboarding.