Senior Scientist, Translational Proteomics, Mass Spectrometry
AstraZeneca

Senior Scientist, Translational Proteomics, Mass Spectrometry

Gaithersburg, MD

Are you a passionate and experienced scientist with a background in Mass Spectrometry and Clinical Proteomics? If so, AstraZeneca is looking for you! We are seeking a motivated individual to join our Translational Proteomics team within our Cancer Biomarker Development (CBD) group. This is an exciting opportunity to apply your expertise and make a significant impact on the clinical development of oncology drugs with innovative biomarkers.

Accountabilities:

In this role, you will be responsible for developing and applying mass spectrometry-based proteomics workflows for biomarker quantification in clinical samples. This will accelerate the development of AZ's oncology medicines. Your duties will include designing and implementing GCP-compliant targeted mass spectrometry assays for biomarker studies, processing clinical samples for translational and clinical studies, operating high-resolution LC-MS instruments, analyzing data, summarizing results, and presenting key results internally and externally. You will also collaborate with translational medicine and bioinformatics teams to develop protein biomarkers.

Essential Skills/Experience:

• Ph.D. in bioanalytical chemistry or related field with 0-3 years post-doctoral experience in quantitative mass spectrometry-based proteomics.
• Extensive experience acquiring and analyzing quantitative mass spectrometry-based proteomic data.
• Extensive hands-on experience with LC-MS instrumentation for operation, maintenance, troubleshooting, quality control, and standardization for proteomics workflows.
• Experience with human biological sample preparation for quantitative LC-MS applications.
• Proficient programming skills (R, Python) for advanced data analysis and visualization.
• Experience in working independently and collaboratively, with strong communication skills.

Desirable Skills/Experience:

• Experience in targeted proteomics, PRM/SRM assay development and definition of limits of quantitation.
• Experience working in a GLP/GCP-regulated environment.
• Experience with liquid handling robotics.

At AstraZeneca, we are united in our vision to eliminate cancer as a cause of death. We are pioneers in the field of Oncology, pushing the boundaries of science to transform the lives of patients living with cancer. With one of the broadest and deepest Oncology pipelines in the industry, we offer many opportunities to work with new and novel drugs. We foster a culture of courage and curiosity, where everyone is empowered to take smart risks, challenge the norm, and learn from failures. We believe in growing together and providing a place where everyone can have a voice. Join us in our mission to make big paradigm shifts in treatment options and make a meaningful difference to people and patients around the world.

About Our Gaithersburg Oncology Hub

The Gaithersburg site (https://www.youtube.com/watch?v=GOvxXGjBd1w) employs more than 3,500 experts in our field and is only a short drive from Washington, DC. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg campus offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, game rooms, community garden and much more.

At AstraZeneca's Oncology R&D department, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next.

We believe in growing together and providing a place where everyone can have a voice. Ambitious and collaborative, we're optimistic in our ability to be resilient and work together towards a cure.

Ready to make a difference? Apply today and join us in our mission to eliminate cancer as a cause of death!

If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: April 24 , 2024

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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